abstract：:The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope (E) protein possesses specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation, which are known to play various role...

journal_title：Virology

authors： Stodola JK,Dubois G,Le Coupanec A,Desforges M,Talbot PJ

更新日期：2018-02-01 00:00:00

abstract：:Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular m...

journal_title：Virology

authors： Chua BA,Ngo JA,Situ K,Ramirez CM,Nakano H,Morizono K

更新日期：2018-02-01 00:00:00

abstract：:Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, deri...

journal_title：Virology

authors： Monteiro JMC,Oliveira MD,Dias RS,Nacif-Marçal L,Feio RN,Ferreira SO,Oliveira LL,Silva CC,Paula SO

更新日期：2018-01-15 00:00:00

abstract：:Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made ...

journal_title：Virology

authors： Gurumayum S,Brahma R,Naorem LD,Muthaiyan M,Gopal J,Venkatesan A

更新日期：2018-01-15 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) induces breast cancer in mice in the absence of known virally-encoded oncogenes. Tumorigenesis by MMTV is thought to occur primarily through insertional mutagenesis, leading to the activation of cellular proto-oncogenes and outgrowth of selected cells. Here we investigated whether MMTV...

journal_title：Virology

authors： Kincaid RP,Panicker NG,Lozano MM,Sullivan CS,Dudley JP,Mustafa F

更新日期：2018-01-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) is a widespread pathogen that persists for life, replicating in surface tissues and establishing latency in peripheral ganglia. Increasingly, molecular studies of latency use cultured neuron models developed using recombinant viruses such as HSV-1 GFP-US11, a derivative of strain Patton ...

journal_title：Virology

authors： Pourchet A,Copin R,Mulvey MC,Shopsin B,Mohr I,Wilson AC

更新日期：2017-12-01 00:00:00

abstract：:RSV is a major cause of severe lower respiratory infection in infants and young children. With no vaccine yet available, it is important to clarify mechanisms of disease pathogenesis. Since indoleamine-2,3-dioxygenase (IDO) is an immunomodulatory enzyme and is upregulated with RSV infection, we studied it in vivo duri...

journal_title：Virology

authors： Rajan D,Chinnadurai R,O'Keefe EL,Boyoglu-Barnum S,Todd SO,Hartert TV,Galipeau J,Anderson LJ

更新日期：2017-12-01 00:00:00

abstract：:Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fu...

journal_title：Virology

authors： Wang W,Yang L,Huang X,Fu W,Pan D,Cai L,Ye J,Liu J,Xia N,Cheng T,Zhu H

更新日期：2017-12-01 00:00:00

abstract：:The parapoxvirus Orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host-innate and pro-inflammatory responses and has been proposed as a vaccine delivery vector for use in animal species. Here we describe the construction and characterization of two recombinant ORFV vectors expressing the...

journal_title：Virology

authors： Martins M,Joshi LR,Rodrigues FS,Anziliero D,Frandoloso R,Kutish GF,Rock DL,Weiblen R,Flores EF,Diel DG

更新日期：2017-11-01 00:00:00

abstract：:Chikungunya virus (CHIKV) infection leads to activation of innate immune response by triggering Toll-like receptor (TLR) pathways resulting in elevated cytokines and type-I interferon levels. Genetic variations of these genes may influence human CHIKV-susceptibility and disease progression. Present study aimed to iden...

journal_title：Virology

authors： Dutta SK,Tripathi A

更新日期：2017-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a confirmed risk factor for hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) possesses tumor suppression function that is frequently defective in HCC tumors. PTEN-Long, a translation isoform of PTEN, functions in a cell non-autonomous m...

journal_title：Virology

authors： Wu Q,Li Z,Liu Q

更新日期：2017-11-01 00:00:00

abstract：:CD8+ T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8+ T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and examined surface proteins, cytoki...

journal_title：Virology

authors： Liu M,Barton ES,Jennings RN,Oldenburg DG,Whirry JM,White DW,Grayson JM

更新日期：2017-09-01 00:00:00

abstract：:Mannose binding lectin (MBL) is a collagenous C-type lectin, which plays an important role in innate immunity. It can bind to carbohydrates on the surface of a wide range of pathogens, including viruses. Here we studied the antiviral effect of recombinant chicken (rc)MBL against Infectious Bronchitis Virus (IBV), a hi...

journal_title：Virology

authors： Zhang W,Bouwman KM,van Beurden SJ,Ordonez SR,van Eijk M,Haagsman HP,Verheije MH,Veldhuizen EJA

更新日期：2017-09-01 00:00:00

abstract：:The bipartite genomic RNAs of red clover necrotic mosaic virus (RCNMV) lack a 5' cap and a 3' poly(A) tail. RNA1 encodes viral replication proteins, and RNA2 encodes a movement protein (MP). These proteins are translated in a cap-independent manner. We previously identified two cis-acting RNA elements that cooperative...

journal_title：Virology

authors： Tajima Y,Iwakawa HO,Hyodo K,Kaido M,Mise K,Okuno T

更新日期：2017-09-01 00:00:00

abstract：:We recently showed that E6 protein of human papillomavirus (HPV) 16, a mucosal high-risk α-PV type, can potentiate Wnt/β-catenin/TCF signaling. Here we investigated the transcriptional activities of E6 proteins of cutaneous HPV types from the β and α genera. Results from reporter-gene assays showed that similar to HPV...

journal_title：Virology

authors： Sominsky S,Shterzer N,Jackman A,Shapiro B,Yaniv A,Sherman L

更新日期：2017-09-01 00:00:00

abstract：:Groundnut bud necrosis virus induces necrotic symptoms in different hosts. Previous studies showed reactive oxygen species-mediated programmed cell death (PCD) resulted in necrotic symptoms. Transgenic expression of viral protein NSs mimics viral symptoms. Here, we showed a role for NSs in influencing oxidative burst ...

journal_title：Virology

authors： Singh A,Permar V,Jain RK,Goswami S,Kumar RR,Canto T,Palukaitis P,Praveen S

更新日期：2017-08-01 00:00:00

abstract：:In mid-January 2016, an outbreak of H7N8 high-pathogenicity avian influenza virus (HPAIV) in commercial turkeys occurred in Indiana. Surveillance within the 10km control zone identified H7N8 low-pathogenicity avian influenza virus (LPAIV) in nine surrounding turkey flocks but no other HPAIV-affected premises. We seque...

journal_title：Virology

authors： Lee DH,Torchetti MK,Killian ML,Swayne DE

更新日期：2017-07-01 00:00:00

abstract：:Many tumors, including cervical carcinoma, show dysregulated expression of the microRNA processing machinery, specifically DROSHA and DICER. Some cervical cancers exhibit chromosome 5p amplifications and DROSHA is the most significantly upregulated transcript and is observed in all tumors with 5p gain. DROSHA and DICE...

journal_title：Virology

authors： Harden ME,Munger K

更新日期：2017-07-01 00:00:00

abstract：:Pseudorabies virus (PRV) China reference strain Ea is genetically closely related to newly emerged variants; however, there is limited information about PRV Ea. Here, we compared PRV Ea with new variant strains by growth kinetics, genome sequencing, and protein expression analysis. Growth analysis showed that strain E...

journal_title：Virology

authors： Wang X,Wu CX,Song XR,Chen HC,Liu ZF

更新日期：2017-06-01 00:00:00

abstract：:Fiber and penton base overproduced in adenovirus (Ad) infected cells can be secreted prior to progeny release and thereby regulate progeny spread. We aimed to investigate the mechanisms of fiber and penton base secretion in Ad2- or Ad5-infected A549 cells. Our flow cytometry analyses detected abundant surface fiber mo...

journal_title：Virology

authors： Yan Y,Zhang B,Hou W,Lin H,Rebetz J,Hong SS,Wang Y,Ran L,Fan X

更新日期：2017-05-01 00:00:00

abstract：:Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to improve nAb response...

journal_title：Virology

authors： Crooks ET,Osawa K,Tong T,Grimley SL,Dai YD,Whalen RG,Kulp DW,Menis S,Schief WR,Binley JM

更新日期：2017-05-01 00:00:00

abstract：:The recently described taxon Negevirus is comprised of a diverse group of insect-specific viruses isolated from mosquitoes and phlebotomine sandflies. In this study, a comprehensive genetic characterization, molecular, epidemiological and evolutionary analyses were conducted on nearly full-length sequences of 91 new n...

journal_title：Virology

authors： Nunes MRT,Contreras-Gutierrez MA,Guzman H,Martins LC,Barbirato MF,Savit C,Balta V,Uribe S,Vivero R,Suaza JD,Oliveira H,Nunes Neto JP,Carvalho VL,da Silva SP,Cardoso JF,de Oliveira RS,da Silva Lemos P,Wood TG,Widen SG

更新日期：2017-04-01 00:00:00

abstract：:Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX). IE1 showed ...

journal_title：Virology

authors： Hornig J,Choi KY,McGregor A

更新日期：2017-04-01 00:00:00

abstract：:Central African tropical forests are home to several species of non-human primates (NHPs), infected by Simian Immunodeficiency Virus (SIV). It is well-known that HIV-1 epidemic is due to cross-transmission and adaptation of SIV to humans. The main goal of this work was to investigate if a NHP bite is a risk factor for...

journal_title：Virology

authors： Filippone C,de Oliveira F,Betsem E,Schaeffer L,Fontanet A,Lemée V,Gessain A,Plantier JC

更新日期：2017-03-01 00:00:00

abstract：:Infections of amphibians by Frog Virus 3 (FV3) and other ranavirus genus members are significantly contributing to the amphibian declines, yet much remains unknown regarding amphibian antiviral immunity. Notably, amphibians represent an important step in the evolution of antiviral interferon (IFN) cytokines as they ar...

journal_title：Virology

authors： Wendel ES,Yaparla A,Koubourli DV,Grayfer L

更新日期：2017-03-01 00:00:00

abstract：:Unusual Plum pox virus (PPV) isolates (named Tat isolates) were discovered on sour cherry (Prunus cerasus) in Russia. They failed to be recognized by RT-PCR using commonly employed primers specific to the strains C or CR (the only ones that proved able to infect sour cherry) as well as to the strains M and W. Some of ...

journal_title：Virology

authors： Chirkov S,Ivanov P,Sheveleva A,Zakubanskiy A,Osipov G

更新日期：2017-02-01 00:00:00

abstract：:Small non-coding microRNAs (miRNAs) can modulate the outcome of virus infection. Here we explore the role of miRNAs in insect-virus interactions, in vivo, using the natural Drosophila melanogaster-Drosophila C virus (DCV) model system. Comparison of the miRNA expression profiles in DCV-infected and uninfected flies sh...

journal_title：Virology

authors： Monsanto-Hearne V,Tham ALY,Wong ZS,Asgari S,Johnson KN

更新日期：2017-02-01 00:00:00

abstract：:Expression of Kaposi's sarcoma herpesvirus vFLIP, a potent activator of NFkB signaling, promotes latency. Inhibition of NFkB signaling promotes lytic reactivation. We previously reported that lytic inducer, RTA, inhibits vFLIP induced NFkB signaling by inducing the degradation of vFLIP via the proteasome. Here we repo...

journal_title：Virology

authors： Chmura JC,Herold K,Ruffin A,Atuobi T,Fabiyi Y,Mitchell AE,Choi YB,Ehrlich ES

更新日期：2017-01-15 00:00:00

abstract：:Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K242 and K244 are resp...

journal_title：Virology

authors： Tan CW,Sam IC,Lee VS,Wong HV,Chan YF

更新日期：2017-01-15 00:00:00

abstract：:Infection of adherent cell monolayers using a liquid inoculum represents an established method to reliably and quantitatively study virus infection, but poorly recapitulates the exposure and infection of cells in the respiratory tract that occurs during infection with aerosolized pathogens. To better simulate natural ...

journal_title：Virology

authors： Creager HM,Zeng H,Pulit-Penaloza JA,Maines TR,Tumpey TM,Belser JA

更新日期：2017-01-01 00:00:00

abstract：:Foot-and-mouth-disease (FMD) remains the most infectious livestock disease worldwide. Although commercially available inactivated or adenovirus-vectored-vaccines (Ad5-FMD) are effective, they require 5-7 days to induce protection. Therefore, new control strategies that stimulate rapid immune responses are needed. Expr...

journal_title：Virology

authors： Diaz-San Segundo F,Montiel NA,Sturza DF,Perez-Martin E,Hickman D,Ramirez-Medina E,Grubman MJ,de Los Santos T

更新日期：2016-12-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) orf5 (Bm5) is a core gene of lepidopteran baculoviruses and encodes the protein with the conserved amino acid residues (DUF3627) in its C-terminus. Here, we found that Bm5 disruption resulted in lower titers of budded viruses and fewer numbers of occlusion bodies (OBs) in B. mo...

journal_title：Virology

authors： Kokusho R,Koh Y,Fujimoto M,Shimada T,Katsuma S

更新日期：2016-11-01 00:00:00

abstract：:The host-virus interaction during the cellular entry of Japanese encephalitis virus (JEV) is poorly characterized. The ubiquitin-proteasome system (UPS), the major intracellular proteolytic pathway, mediates diverse cellular processes, including endocytosis and signal transduction, which may be involved in the entry o...

journal_title：Virology

authors： Wang S,Liu H,Zu X,Liu Y,Chen L,Zhu X,Zhang L,Zhou Z,Xiao G,Wang W

更新日期：2016-11-01 00:00:00

abstract：:IFN responses control acute HSV infection, but their role in regulating HSV latency is poorly understood. To address this we used mice lacking IFN signaling specifically in neural tissues. These mice supported a higher acute viral load in nervous tissue and delayed establishment of latency. While latent HSV-1 genome c...

journal_title：Virology

authors： Rosato PC,Katzenell S,Pesola JM,North B,Coen DM,Leib DA

更新日期：2016-10-01 00:00:00

abstract：:Human Cytomegalovirus (HCMV) infection is compromised in cells lacking p53, a transcription factor that mediates cellular stress responses. In this study we have investigated compromised functional virion production in cells with p53 knocked out (p53KOs). Infectious center assays found most p53KOs released functional ...

journal_title：Virology

authors： Kuan MI,O'Dowd JM,Chughtai K,Hayman I,Brown CJ,Fortunato EA

更新日期：2016-10-01 00:00:00

abstract：:Expansion of CHIKV outbreaks with appearance of novel mutations are reported from many parts of the world. Two novel mutations viz. E1:K211E and E2:V264A in background of E1:226A are recently identified from Aedes aegypti dominated areas of India. In this study, the role of these mutations in modulation of infectivity...

journal_title：Virology

authors： Agarwal A,Sharma AK,Sukumaran D,Parida M,Dash PK

更新日期：2016-10-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and pneumonia in infants and pneumonia virus of mice (PVM) causes similar disease. BALB/c mice are highly susceptible, while C57BL/6 mice are more resistant to PVM. IL-12 was significantly more up-regulated in response to PVM infection in BALB/c than ...

journal_title：Virology

authors： Shrivastava P,Sarkar I,Atanley E,Gomis S,van Drunen Littel-van den Hurk S

更新日期：2016-10-01 00:00:00

abstract：:Influenza antiviral drugs that use protein inhibitors can lose their efficacy as resistant strains emerge. As an alternative strategy, we investigated the use of small interfering RNA molecules (siRNAs) by characterizing three siRNAs (M747, M776 and M832) targeting the influenza matrix 2 gene and three (NS570, NS595 a...

journal_title：Virology

authors： McMillen CM,Beezhold DH,Blachere FM,Othumpangat S,Kashon ML,Noti JD

更新日期：2016-10-01 00:00:00

abstract：:The post-entry events of HIV-1 infection occur within reverse transcription complexes derived from the viral cores entering the target cell. HIV-1 cores contain host proteins incorporated from virus-producing cells. In this report, we show that MCM5, a subunit of the hexameric minichromosome maintenance (MCM) DNA heli...

journal_title：Virology

authors： Santos S,Obukhov Y,Nekhai S,Pushkarsky T,Brichacek B,Bukrinsky M,Iordanskiy S

更新日期：2016-10-01 00:00:00

abstract：:Within immunocompromised populations, the JC polyomavirus is the cause of the often-fatal disease Progressive Multifocal Leukoencephalopathy (PML). JC virus encodes a protein, termed T-antigen (T-ag), which is essential for its replication and pathogenicity. Previous studies of JCV T-ag have, in general, used antibodi...

journal_title：Virology

authors： Grubman SA,Shin J,Phelan PJ,Gong A,Can H,Dilworth R,Kini SK,Gagnon D,Archambault J,Meinke G,Bohm A,Jefferson DM,Bullock PA

更新日期：2016-10-01 00:00:00